Department of Chemistry is as old as Ruia College. It is one of the biggest Departments catering to about 600 students at the UG & about 250 students at the PG and the doctoral level. The Department of Chemistry has research tradition spanning over half a Century to with more than 250 students having passed out with doctoral degree through the portals of this Institution. Currently the Department has 6 research guides. Department has received grants from the funding agencies like DBT, DST, UGC and CSIR. It has been successfully running Dr. P. S. Ramanathan Advanced Instrumentation Centre, only one of its kind in the city of Mumbai, housing high-end use instruments like HPLC, GC, GC-Ms, AAS.